Endocrine Abstracts

Introduction: Assessing the effect of GLP 1 receptor agonist on metabolic control and weight loss in obesity and type 2 diabetes patients.Description of methods: A retrospective descriptive study involving type 2 diabetes patients and BMI >30 kg/m2, who started treatment with GLP-1-RAs during the years 2012–2014. Variables analyzed: weight and HbA1c at the begging, 6 months, 1 and 2 years; regimen at baseline and after GLP-1-RAs; inci...

Introduction: Myxoid tumors of the adrenal glands constitute an unusual entity and should be part of the differential diagnosis of atypical adenomas in the study of adrenal incidentaloma.Description of methods: We report the finding of myxoid adrenal adenoma in left adrenal gland in a 38-year-old woman.Case: PMH: Active smoker. Non hypertension, type 2 diabetes or dyslipidemia. No constitutional symptoms.Phys...

RF-amide-related peptide-3 (RFRP-3), the mammalian orthologue of the avian gonadotropin-inhibiting hormone (GnIH), has been proposed as major inhibitory signal for the reproductive axis, acting via the NPFF1 receptor (NPFF1R). In addition, RFRP-3 has been recently suggested to modulate feeding, with reported orexigenic actions; a function that might contribute to the integrative control of energy homeostasis and reproduction. However, characterisation of the metabolic effects ...

While female fertility is known to be sensitive to conditions of low body fuel reserves, the reproductive consequences of persistent energy excess remain ill defined. Yet, the pandemic proportions of obesity, and its potential impact on the gonadotropic axis, call for a better understanding of this phenomenon. Alike, the influence of ovarian hormones on the pathophysiology of obesity and its complications merits further investigation. In this work, we aimed to elucidate the me...

Introduction: There are new therapies indicated in medullary thyroid cancer (MTC) based on different molecular targets, that appear to be effective in some cases with advanced disease, although many are still under investigation.Material and methods: We retrospectively evaluated five cases of medullar thyroid advanced carcinoma that later were referred to Oncology Department for Chemotherapy treatment.Results: Five patients (mean a...

Introduction: Betablockers are not a first-line antihypertensive therapy, although they have specific cardiological indications. The use of betablockers, especially the non-selective ones, may be associated with paradoxical hypertension, due to unopposed alpha-adrenergic peripheral vasoconstriction.Methods: Review of the patient’s Clinical Record and of the relevant literature.Results: Clinical Case: A 66 year old woman was r...

Vasoinhibin, historically also known as 16K PRL, is a peptide hormone with antiangiogenic, antivasodilatatory, and antivasopermeability effects generated by proteolytic cleavage of prolactin (PRL). The discovery of its role in diabetic retinopathy and peripartum cardiomyopathy led to the development of new pharmacological treatments and their evaluation in clinical interventional trials (ClinicalTrials.gov Identifier: NCT03161652 and NCT00998556). Recent insights into the func...

Introduction: Silymarin is a standardized extract of the milk thistle (Sylibum marianum) seeds, containing a mixture of flavonolignans: silybinin, isosilybinin, silycristin, silydianin, and others. It is used in the treatment of toxic liver damage and as adjunctive therapy in chronic hepatitis and cirrhosis. Recent studies have shown a potential benefit in the treatment of diabetes mellitus and non-alcoholic fatty liver disease. We undertook to study the effect of silymarin on...

Introduction: Cystic fibrosis (CF) is a chronic disease at risk of malnutrition. The aim of the study is to assess nutritional status of patients with CF.Methods: Descriptive study of CF patients referred for a nutritional evaluation. Data collected included lung function, pancreatic and carbohydrate metabolism (according to ADA’s diagnostic criteria), anthropometric and laboratory parameters. Results are shown as mean (S.D.).<p c...

Objective: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are relatively infrequent. We present a descriptive study of GEP-NETs of a reference Spanish hospital.Patients and methods: Forty-six patients were diagnosed of GEP-NETs during the period 1993–2011. Data regarding demographic, clinical, analytical, anatomopathological and diagnostic variables were collected. Results are expressed as mean±SD....